Some characteristics of ephaptic transmission of action potentials were investigated with squid giant axons. For these studies two isolated axons were placed. Thus, the secondary peaks must represent the orthodromic impulses generated by ephaptic transmission. An average inter-peak interval of ms between the. Ephaptic transmission was implied. NEUROLOGY (Ny) ; Aberrant conduction in human peripheral nerve: Ephaptic transmission? Richard A.

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Although the exact functional role of this inhibition is still unclear, it may well have a synchronizing effect in the Purkinje cells as the ephaptic effect will limit the firing time.

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These changes were attributed to the local currents that form the action potential. It was found that rhythmic electrical discharge associated with fetal neurons in the rat spinal cord and medulla was still sustained. This finding implicates the antidromic motor impulse as the trigger for lateral spread.

A similar ephaptic effect has been studied in the Mauthner cells of teleosts. Have your cake and eat pie too.

A hypothesis or explanation behind the mechanism is “one-way”, “master-slave”, or “unidirectional synchronization” effect as mathematical and fundamental property of non-linear dynamic systems oscillators like neurons to synchronize under certain criteria. Take the quiz Name That Thing Test your visual vocabulary with our question transmsision It is concluded that in regions in which axons are confined by restricted extracellular volume, the large extracellular voltage changes arising during the passage of an action potential in one can cause ephaptic excitation in another.


Epileptic seizures occur when there is synchrony of electrical ephqptic in the brain.

Ephaptic transmission is the origin of the abnormal muscle response seen in hemifacial spasm.

They tested the effects of changing extracellular space which affects local electrical fields and found that one can block epileptic synchronization independent of chemical synapse manipulation simply by increasing the space between cells. Whether it is a true lack of evidence or simply obstinance in the face of change, many in the field are still not entirely convinced there is unambiguous evidence of ephaptic coupling. Literally How to use a word that literally drives some people nuts.

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Understanding the brain languageIOS Press, doi: Need even more definitions? Many people believed that the micro electrical fields produced by the neurons themselves were so small that they were negligible.

ephaptic transmission

Simultaneous action potential firing caused interference and resulted in decreased conduction velocitywhile slightly offset stimulation resulted in synchronization of the epha;tic impulses. Knowing the role that ephaptic coupling plays in fphaptic synchrony in electrical signals, it makes sense to look for ephaptic mechanisms in this type of pathology. Dictionary Entries near ephaptic eperythrozoon eperythrozoonosis ephapse ephaptic ephedra ephedrine ephelis.

What made you want to look up ephaptic? Hence the phenomenon is of not only fundamental interest but also applied one from treating epilepsy to novel learning systems. It may refer to trznsmission coupling of adjacent touching nerve fibers caused by the exchange of ions between the cells, or it may refer to coupling of nerve fibers as a result of local electric fields.


The idea that the electrical activity generated by nervous tissue may influence the activity of surrounding nervous tissue is one that dates back to the late 19th century. One study suggested that cortical cells represent an ideal place to observe ephaptic coupling due to the tight packing of axons, which allows for interactions between their electrical fields.

This was accomplished in one study in two experimental conditions: This page was last edited on 11 Novemberat In the simpler case of adjacent fibers that experience simultaneous stimulation the impulse is slowed because both fibers are limited to exchange ions solely with the interstitial fluid increasing the resistance of the nerve. Inbasic tests were being conducted on squid giant axons in order to find evidence of ephaptic events. Early experiments, like those by du Bois-Reymond, [3] demonstrated that the firing of a primary nerve may induce the firing of an adjacent secondary nerve termed “secondary excitation”.

This inhibition has been shown to occur from changes in electrical potentials alone.

An average inter-peak interval of 1. By using this site, you agree to the Terms of Use and Privacy Policy. How to use a word that literally drives ephwptic people nuts. This effect has been demonstrated and modeled in a variety of cases.